abstract：BACKGROUND:With advances in cell capture, gene expression can now be studied in neuronal subtypes and single cells; however, studying epigenetic mechanisms that underlie these changes presents challenges. Moreover, chromatin immunoprecipitation (ChIP) protocols optimized for low cell number do not adequately address te...

journal_title：Journal of neuroscience methods

authors： Finegersh A,Homanics GE

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Machine learning models have been successfully applied to neuroimaging data to make predictions about behavioral and cognitive states of interest. While these multivariate methods have greatly advanced the field of neuroimaging, their application to electrophysiological data has been less common especially i...

journal_title：Journal of neuroscience methods

authors： Schrouff J,Mourão-Miranda J,Phillips C,Parvizi J

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Windowed Fourier decompositions (WFD) are widely used in measuring stationary and non-stationary spectral phenomena and in describing pairwise relationships among multiple signals. Although a variety of WFDs see frequent application in electrophysiological research, including the short-time Fourier transform...

journal_title：Journal of neuroscience methods

authors： Kovach CK,Gander PE

更新日期：2016-03-01 00:00:00

abstract：:In order to understand the pathophysiology of temporal lobe epilepsy (TLE), and thus to develop new pharmacological treatments, in vivo animal models that present features similar to those seen in TLE patients have been developed during the last four decades. Some of these models are based on the systemic administrati...

journal_title：Journal of neuroscience methods

authors： Lévesque M,Avoli M,Bernard C

更新日期：2016-02-15 00:00:00

abstract：:The neocortex is the site of origin of several forms of acquired epilepsy. Here we provide a brief review of experimental models that were recently developed to study neocortical epileptogenesis as well as some major results obtained with these methods. Most of neocortical seizures appear to be nocturnal and it is kno...

journal_title：Journal of neuroscience methods

authors： Chauvette S,Soltani S,Seigneur J,Timofeev I

更新日期：2016-02-15 00:00:00

abstract：:Experimental animal epilepsy research got a big boost since the discovery that daily mild and short (seconds) tetanic stimulations in selected brain regions led to seizures with increasing duration and severity. This model that was developed by Goddard (1967) became known as the kindling model for epileptogenesis and ...

journal_title：Journal of neuroscience methods

authors： Gorter JA,van Vliet EA,Lopes da Silva FH

更新日期：2016-02-15 00:00:00

abstract：BACKGROUND:Intraparenchymal convection-enhanced delivery (CED) of therapeutics directly into the brain has long been endorsed as a medium through which meaningful concentrations of drug can be administered to patients, bypassing the blood brain barrier. The translation of the technology to clinic has been hindered by p...

journal_title：Journal of neuroscience methods

authors： Lewis O,Woolley M,Johnson D,Rosser A,Barua NU,Bienemann AS,Gill SS,Evans S

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Steady-state visual-evoked potential (SSVEP)-based brain-computer interfaces (BCIs) generate weak SSVEP with a monitor and cannot use harmonic frequencies, whereas P300-based BCIs need multiple stimulation sequences. These issues can decrease the information transfer rate (ITR). NEW METHOD:In this paper, we...

journal_title：Journal of neuroscience methods

authors： Chang MH,Lee JS,Heo J,Park KS

更新日期：2016-01-30 00:00:00

abstract：BACKGROUND:Connectivity analysis in magnetoencephalography (MEG) sensor space is commonly used for the preliminary estimation of the functional relationship between cortical areas, but the results are difficult to interpret due to the field spread effect. To improve the interpretability of sensor-level connectivity ana...

journal_title：Journal of neuroscience methods

authors： Kim MY,Kwon H,Lim S,Lee YH,Kim JW,Kim K

更新日期：2016-01-15 00:00:00

abstract：BACKGROUND:Secondary hyperalgesia is increased sensitivity in normal tissue near an injury, and it is a measure of central sensitization reflecting injury-related effects on the CNS. Secondary hyperalgesia areas (SHAs), usually assessed by polyamide monofilaments, are important outcomes in studies of analgesic drug eff...

journal_title：Journal of neuroscience methods

authors： Ringsted TK,Enghuus C,Petersen MA,Werner MU

更新日期：2015-12-30 00:00:00

abstract：BACKGROUND:Transcranial magnetic stimulation (TMS) can evaluate cortical excitability and integrity of motor pathways via TMS-induced responses. The responses are affected by the orientation of the stimulated neurons with respect to the direction of the TMS-induced electric field. Therefore, besides being a functional ...

journal_title：Journal of neuroscience methods

authors： Kallioniemi E,Könönen M,Säisänen L,Gröhn H,Julkunen P

更新日期：2015-12-30 00:00:00

abstract：BACKGROUND:Dilated brain perivascular spaces (PVSs) are found to be associated with many conditions, including aging, dementia, and Alzheimer's disease (AD). Conventionally, PVS assessment is mainly based on subjective observations of the number, size and shape of PVSs in MR images collected at clinical field strengths...

journal_title：Journal of neuroscience methods

authors： Cai K,Tain R,Das S,Damen FC,Sui Y,Valyi-Nagy T,Elliott MA,Zhou XJ

更新日期：2015-12-30 00:00:00

abstract：BACKGROUND:Normal defaecation involves activation of anorectal mechanoreceptors responsive to pressure and stretch. The aim of this study was to develop selective anal and rectal mucosal light-touch stimulation suitable for measurement of cortical evoked potentials (EPs) in order to explore the sensory arm of these pat...

journal_title：Journal of neuroscience methods

authors： Carrington EV,Evers J,Scott SM,Knowles CH,O'Connell PR,Jones JF

更新日期：2015-12-30 00:00:00

abstract：BACKGROUND:Magnetic resonance imaging and spectroscopy (MRI-MRS) is a useful tool for the identification and evaluation of chemical changes in anatomical regions. Quality assurance (QA) is performed in either images or spectra using QA phantom. Therefore, consistent and uniform technical MRI-MRS QA is crucial. NEW MET...

journal_title：Journal of neuroscience methods

authors： Song KH,Kim SY,Lee DW,Jung JY,Lee JH,Baek HM,Choe BY

更新日期：2015-11-30 00:00:00

abstract：BACKGROUND:Combining both high temporal and spatial resolution by means of simultaneous electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) is of relevance to neuroscientists. This combination, however, leads to a distortion of the EEG signal by the so-called cardio-ballistic artefacts. The ai...

journal_title：Journal of neuroscience methods

authors： Abbasi O,Dammers J,Arrubla J,Warbrick T,Butz M,Neuner I,Shah NJ

更新日期：2015-11-30 00:00:00

abstract：BACKGROUND:In this paper exploitation of correlation between post-movement beta rebound in EEG and blood oxygenation level dependent (BOLD) in fMRI is addressed. Brain studies do not reveal any clear relationship between synchronous neuronal activity and BOLD signal. Simultaneous recording of EEG and fMRI provides a gr...

journal_title：Journal of neuroscience methods

authors： Ferdowsi S,Abolghasemi V,Sanei S

更新日期：2015-10-30 00:00:00

abstract：INTRODUCTION:Our aim was to assess differences in movement measures in attention-deficit/hyperactivity disorder (ADHD) vs. typically developing (TD) controls. METHODS:We performed meta-analyses of published studies on motion measures contrasting ADHD with controls. We also conducted a case-control study with children/...

journal_title：Journal of neuroscience methods

authors： García Murillo L,Cortese S,Anderson D,Di Martino A,Castellanos FX

更新日期：2015-08-30 00:00:00

abstract：BACKGROUND:Tinnitus, head and ear noise, is due to maladaptive plastic changes in auditory and associated neural networks. Tinnitus has been traditionally managed through the use of sound to passively mask or facilitate habituation to tinnitus, a process that may take 6-12 months. NEW METHOD:A game-based perceptual tr...

journal_title：Journal of neuroscience methods

authors： Wise K,Kobayashi K,Searchfield GD

更新日期：2015-07-15 00:00:00

abstract：BACKGROUND:Stroke is the third leading cause of death and the leading cause of long-term disability in North America. On average, someone in the US has a stroke every 45 s, and worldwide, stroke claims 15 million lives each year. Therefore, reliable stroke models are vital to the production of effective new therapies f...

journal_title：Journal of neuroscience methods

authors： Smith HK,Russell JM,Granger DN,Gavins FN

更新日期：2015-07-15 00:00:00

abstract：BACKGROUND:Microelectrode arrays have been used successfully for neuronal stimulation both in vivo and in vitro. However, in most instances currents required to activate the neurons have been in un-physiological ranges resulting in neuronal damage and cell death. There is a need to develop electrodes which require less...

journal_title：Journal of neuroscience methods

authors： Ghazavi A,Westwick D,Xu F,Wijdenes P,Syed N,Dalton C

更新日期：2015-06-15 00:00:00

abstract：BACKGROUND:Flow cytometry is an efficient and powerful technique to characterize and quantify numerous cells. However, the strengths of this technique have not been widely harnessed in neurosciences due to the critical step of CNS tissue preparation into a single cell suspension. Previous reports assessed either neural...

journal_title：Journal of neuroscience methods

authors： Legroux L,Pittet CL,Beauseigle D,Deblois G,Prat A,Arbour N

更新日期：2015-05-30 00:00:00

abstract：BACKGROUND:There is a need for effective computational methods for quantifying the three-dimensional (3-D) spatial distribution, cellular arbor morphologies, and the morphological diversity of brain astrocytes to support quantitative studies of astrocytes in health, injury, and disease. NEW METHOD:Confocal fluorescenc...

journal_title：Journal of neuroscience methods

authors： Kulkarni PM,Barton E,Savelonas M,Padmanabhan R,Lu Y,Trett K,Shain W,Leasure JL,Roysam B

更新日期：2015-05-15 00:00:00

abstract：BACKGROUND:Providing weight support facilitates locomotion in spinal cord injured animals. To control weight support, robotic systems have been developed for treadmill stepping and more recently for overground walking. NEW METHOD:We developed a novel device, the body weight supported ambulatory rodent trainer (i.e. BA...

journal_title：Journal of neuroscience methods

authors： Hamlin M,Traughber T Jr,Reinkensmeyer DJ,de Leon RD

更新日期：2015-05-15 00:00:00

abstract：BACKGROUND:The assessment of directed functional connectivity from neuronal data is increasingly common in neuroscience by applying measures based in the Granger causality (GC) framework. Although initially these consisted in simple analyses based on directionality strengths, current methods aim to discriminate causal ...

journal_title：Journal of neuroscience methods

authors： Rodrigues J,Andrade A

更新日期：2015-04-30 00:00:00

abstract：BACKGROUND:Since task related neurons cannot be specifically targeted during surgery, a critical decision to make is to select which neurons are task-related when performing data analysis. Including neurons unrelated to the task degrade decoding accuracy and confound neurophysiological results. Traditionally, task-rela...

journal_title：Journal of neuroscience methods

authors： Kahn K,Saxena S,Eskandar E,Thakor N,Schieber M,Gale JT,Averbeck B,Eden U,Sarma SV

更新日期：2015-04-30 00:00:00

abstract：BACKGROUND:A key point in developmental biology is to understand how gene expression influences the morphological and dynamical patterns that are observed in living beings. NEW METHOD:In this work we propose a methodology capable of addressing this problem that is based on estimating the mutual information and Pearson...

journal_title：Journal of neuroscience methods

authors： de Arruda HF,Comin CH,Miazaki M,Viana MP,Costa Lda F

更新日期：2015-04-30 00:00:00

abstract：:In recent years, various applications of brain computer interfaces (BCIs) have been studied. In this paper, we present a hybrid BCI combining P300 and motor imagery to operate an explorer. Our system is mainly composed of a BCI mouse, a BCI speller and an explorer. Through this system, the user can access his computer...

journal_title：Journal of neuroscience methods

authors： Bai L,Yu T,Li Y

更新日期：2015-04-15 00:00:00

abstract：:Brain-computer interface (BCI) technology has attracted significant attention over recent decades, and has made remarkable progress. However, BCI still faces a critical hurdle, in that performance varies greatly across and even within subjects, an obstacle that degrades the reliability of BCI systems. Understanding th...

journal_title：Journal of neuroscience methods

authors： Ahn M,Jun SC

更新日期：2015-03-30 00:00:00

abstract：BACKGROUND:Recent advances in genetically engineered calcium and membrane potential indicators provide the potential to estimate the activation dynamics of individual neurons within larger, mesoscale networks (100s-1000+neurons). However, a fully integrated automated workflow for the analysis and visualization of neura...

journal_title：Journal of neuroscience methods

authors： Patel TP,Man K,Firestein BL,Meaney DF

更新日期：2015-03-30 00:00:00

abstract：BACKGROUND:Spike-wave discharges (SWD) found in neuroelectrical recordings are pathognomonic to absence epilepsy. The characteristic spike-wave morphology of the spike-wave complex (SWC) constituents of SWDs can be mathematically described by a subset of possible spectral power and phase values. Morlet wavelet transfor...

journal_title：Journal of neuroscience methods

authors： Richard CD,Tanenbaum A,Audit B,Arneodo A,Khalil A,Frankel WN

更新日期：2015-03-15 00:00:00

abstract：BACKGROUND:Military personnel and civilians living in areas of armed conflict have increased risk of exposure to blast overpressures that can cause significant hearing loss and/or brain injury. The equipment used to simulate comparable blast overpressures in animal models within laboratory settings is typically very la...

journal_title：Journal of neuroscience methods

authors： Newman AJ,Hayes SH,Rao AS,Allman BL,Manohar S,Ding D,Stolzberg D,Lobarinas E,Mollendorf JC,Salvi R

更新日期：2015-03-15 00:00:00

abstract：BACKGROUND:Epileptic seizures evolve through several states, and in the process the brain signals may change dramatically. Signals from different states share similar features, making it difficult to distinguish them from a time series; the goal of this work is to build a classifier capable of identifying seizure state...

journal_title：Journal of neuroscience methods

authors： Sotelo A,Guijarro ED,Trujillo L

更新日期：2015-02-15 00:00:00

abstract：BACKGROUND:Recording and manipulating neural activity in awake behaving animal models requires long-term implantation of cranial implants that must address a variety of design considerations, which include preventing infection, minimizing tissue damage, mechanical strength of the implant, and MRI compatibility. NEW ME...

journal_title：Journal of neuroscience methods

authors： Mulliken GH,Bichot NP,Ghadooshahy A,Sharma J,Kornblith S,Philcock M,Desimone R

更新日期：2015-02-15 00:00:00

abstract：BACKGROUND:Advances in MRI have the potential to improve surgical treatment of epilepsy through improved identification and delineation of lesions. However, validation is currently needed to investigate histopathological correlates of these new imaging techniques. The purpose of this work is to develop and evaluate a p...

journal_title：Journal of neuroscience methods

authors： Goubran M,de Ribaupierre S,Hammond RR,Currie C,Burneo JG,Parrent AG,Peters TM,Khan AR

更新日期：2015-02-15 00:00:00

abstract：:The autoregressive (AR) model is widely used in electroencephalogram (EEG) analyses such as waveform fitting, spectrum estimation, and system identification. In real applications, EEGs are inevitably contaminated with unexpected outlier artifacts, and this must be overcome. However, most of the current AR models are b...

journal_title：Journal of neuroscience methods

authors： Li P,Wang X,Li F,Zhang R,Ma T,Peng Y,Lei X,Tian Y,Guo D,Liu T,Yao D,Xu P

更新日期：2015-01-30 00:00:00

abstract：BACKGROUND:Experimental stroke studies use multiple techniques to evaluate histopathological damage. Unfortunately, sensitivity and reproducibility of these techniques are poorly characterized despite pivotal influence on results. METHOD:The present study compared several quantification methods to differentiate betwee...

journal_title：Journal of neuroscience methods

authors： Wang J,Jahn-Eimermacher A,Brückner M,Werner C,Engelhard K,Thal SC

更新日期：2015-01-30 00:00:00

abstract：BACKGROUND:Advancement in clinically relevant studies like seizure interruption using functional neuro imaging tools has shown that specific changes in hemodynamics precede and accompany seizure onset and propagation. However, preclinical seizure experiments need to be conducted in awake animals with images reconstruct...

journal_title：Journal of neuroscience methods

authors： Zhang T,Zhou J,Carney PR,Jiang H

更新日期：2015-01-30 00:00:00

abstract：BACKGROUND:The brain generates signals in a wide frequency range (∼2840 Hz). Existing magnetoencephalography (MEG) methods typically detect brain activity in a median-frequency range (1-70 Hz). The objective of the present study was to develop a new method to utilize the frequency signatures for source imaging. NEW ME...

journal_title：Journal of neuroscience methods

authors： Xiang J,Korman A,Samarasinghe KM,Wang X,Zhang F,Qiao H,Sun B,Wang F,Fan HH,Thompson EA

更新日期：2015-01-15 00:00:00

abstract：BACKGROUND:Deep brain stimulation (DBS) has treatment efficacy in neurological and psychiatric disorders such as Parkinson's disease and major depression. Electroencephalography (EEG) is a versatile neurophysiological tool that can be used to better understand DBS treatment mechanisms. DBS causes artifacts in EEG recor...

journal_title：Journal of neuroscience methods

authors： Sun Y,Farzan F,Garcia Dominguez L,Barr MS,Giacobbe P,Lozano AM,Wong W,Daskalakis ZJ

更新日期：2014-11-30 00:00:00

abstract：BACKGROUND:PET allows the measurement of CBF, CBV and CMRO2 in human and plays an important role in the diagnosis of pathologic conditions and clinical research. On the other hand, in animal studies, there is no optical imaging system for evaluating changes in CBF and CBV, and oxygen metabolism, from the same brain are...

journal_title：Journal of neuroscience methods

authors： Takuwa H,Matsuura T,Nishino A,Sakata K,Tajima Y,Ito H

更新日期：2014-11-30 00:00:00